Publications of Hartmut Wekerle

Skulina, C.; Schmidt, S.; Dornmair, K.; Babbe, H.; Roers, A.; Rajewsky, K.; Wekerle, H.; Hohlfeld, R.; Goebels, N.: Multiple sclerosis: Brain-infiltrating CD8(+) T cells persist as clonal expansions in the cerebrospinal fluid and blood. Proceedings of the National Academy of Sciences of the United States of America 101 (8), pp. 2428 - 2433 (2004)

Kawakami, N.; Lassmann, S.; Li, Z. X.; Odoardi, F.; Ritter, T.; Ziemssen, T.; Klinkert, W. E. F.; Ellwart, J. W.; Bradl, M.; Krivacic, K. et al.; Lassmann, H.; Ransohoff, R. M.; Volk, H. D.; Wekerle, H.; Linington, C.; Flügel, A.: The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis. Journal of Experimental Medicine 199 (2), pp. 185 - 197 (2004)

Dornmair, K.; Goebels, N.; Weltzien, H. U.; Wekerle, H.; Hohlfeld, R.: T-cell-mediated autoimmunity - Novel techniques to characterize autoreactive T-cell receptors. American Journal of Pathology 163 (4), pp. 1215 - 1226 (2003)

Wekerle, H.; Hohlfeld, R.: Molecular mimicry in multiple sclerosis. New England Journal of Medicine 349 (2), pp. 185 - 186 (2003)

Hofbauer, M.; Wiesener, S.; Babbe, H.; Roers, A.; Wekerle, H.; Dornmair, K.; Goebels, N.: Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR, and CDR3-spectratype analysis. Proceedings of the National Academy of Sciences of the United States of America 100 (7), pp. 4090 - 4095 (2003)

Kerschensteiner, M.; Stadelmann, C.; Dechant, G.; Wekerle, H.; Hohlfeld, R.: Neurotrophic cross-talk between the nervous and immune systems: Implications for neurological diseases. Annals of Neurology 53 (3), pp. 292 - 304 (2003)

Wekerle, H.: Immune protection of the brain - Efficient and delicate. The Journal of Infectious Diseases 186 (Suppl. 2), pp. S140 - S144 (2002)

Wekerle, H.: Tackling multiple sclerosis. Nature 420 (6911), pp. 39 - 40 (2002)

Wiendl, H.; Malotka, J.; Holzwarth, B.; Weltzien, H. U.; Wekerle, H.; Hohlfeld, R.; Dornmair, K.: An autoreactive gamma delta TCR derived from a polymyositis lesion. Journal of Immunology 169 (1), pp. 515 - 521 (2002)

Neumann, H.; Schweigreiter, R.; Yamashita, T.; Rosenkranz, K.; Wekerle, H.; Barde, Y. A.: Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a Rho-dependent mechanism. The Journal of Neuroscience 22 (3), pp. 854 - 862 (2002)

Bauer, J.; Bradl, M.; Klein, M.; Leisser, M.; Deckwerth, T. L.; Wekerle, H.; Lassmann, H.: Endoplasmic reticulum stress in PLP-overexpressing transgenic rats: Gray matter oligodendrocytes are more vulnerable than white matter oligodendrocytes. Journal of Neuropathology and Experimental Neurology 61 (1), pp. 12 - 22 (2002)

Flugel, A.; Matsumuro, K.; Neumann, H.; Klinkert, W. E. F.; Birnbacher, R.; Lassmann, H.; Otten, U.; Wekerle, H.: Anti-inflammatory activity of nerve growth factor in experimental autoimmune encephalomyelitis: Inhibition of monocyte transendothelial migration. European Journal of Immunology 31 (1), pp. 11 - 22 (2001)

Medana, I.; Martinic, M. A.; Wekerle, H.; Neumann, H.: Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes. American Journal of Pathology 159 (3), pp. 809 - 815 (2001)

Hohlfeld, R.; Kerschensteiner, M.; Stadelmann, C.; Lassmann, H.; Wekerle, H.: The neuroprotective effect of inflammation: Implications for the therapy of multiple sclerosis. Journal of Neuroimmunology 107 (2), pp. 161 - 166 (2000)

Bradl, M.; Bauer, J.; Inomata, T.; Zielasek, J.; Nave, K. A.; Toyka, K.; Lassmann, H.; Wekerle, H.: Transgenic Lewis rats overexpressing the proteolipid protein gene: Myelin degeneration and its effect on T cell-mediated experimental autoimmune encephalomyelitis. Acta Neuropathologica 97 (6), pp. 595 - 606 (1999)

Kerschensteiner, M.; Gallmeier, E.; Behrens, L.; Vargas-Leal, V.; Misgeld, T.; Klinkert, W. E. F.; Kolbeck, R.; Hoppe, E.; Oropeza-Wekerle, R. L.; Bartke, I. et al.; Stadelmann, C.; Lassmann, H.; Wekerle, H.; Hohlfeld, R.: Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: A neuroprotective role of inflammation? Journal of Experimental Medicine 189 (5), pp. 865 - 870 (1999)

Behrens, L.; Kerschensteiner, M.; Misgeld, T.; Goebels, N.; Wekerle, H.; Hohlfeld, R.: Human muscle cells express a functional costimulatory molecule distinct from B7,1 (CD80) and B7,2 (CD86) in vitro and in inflammatory lesions. Journal of Immunology 161 (11), pp. 5943 - 5951 (1998)

Bauer, J.; Bradl, M.; Hickey, W. F.; Forss-Petter, S.; Breitschopf, H.; Linington, C.; Wekerle, H.; Lassmann, H.: T-cell apoptosis in inflammatory brain lesions - Destruction of T cells does not depend on antigen recognition. American Journal of Pathology 153 (3), pp. 715 - 724 (1998)

Litzenburger, T.; Fässler, R.; Bauer, J.; Lassmann, H.; Linington, C.; Wekerle, H.; Iglesias, A.: B lymphocytes producing demyelinating autoantibodies: Development and function in gene-targeted transgenic mice. Journal of Experimental Medicine 188 (1), pp. 169 - 180 (1998)

Wekerle, H.: The viral triggering of autoimmune disease. Nature Medicine 4 (7), pp. 770 - 771 (1998)